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abituzumab (CAT#: TAB-H01)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Anti-Human ITGAV Recombinant Antibody TAB-H01 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized (from mouse) antibody to Human ITGAV. Abituzumab (EMD 525797)is a humanised monoclonal antibody targeting integrin αν heterodimers.
  • Type
  • IgG2 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, western blot, immunohistochemistry, flow cytometry, immunoaffinity purification and most other immunological methods. ELISA, IP, FC, FuncS, IF, Neut and most other immunological methods.
  • CAS
  • 1105038-73-0
  • Specific Activity
  • ITGAV (integrin alpha V, CD51) [Homo sapiens]
  • Protein Construction
  • gamma2 heavy chain (1-447) with IGHG1 hinge region [humanized VH (Homo sapiens IGHV1-46*01 (77.30%) – (IGHD) – IGHJ6*01) [8.8.11] (1-118)– Homo sapiens IGHG (IGHG2*03 CH1 (119-216), IGHG1 hinge C5>S (221) (217-231), IGHG2*03 CH2 F84.3>A (296), N84.4>Q (297) (232-340), CH3(341-445), CHS (446-447)) (119-447)], (132-214') – disulfide withkappa light chain (1'-214') [humanized V- KAPPA (Homo sapiens IGKV1-33*01 (86.30%) – IGKJ2*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01(108'-214')]; dimer (227-227":230 -230") – bisdisulfide
  • Purity
  • Purity >95% by SDS-PAGE.

BACKGROUND

  • Antigen Description
  • This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
  • Function
  • contributes_to insulin-like growth factor I binding; contributes_to opsonin binding; protein binding; protein kinase C alpha binding; contributes_to protein kinase C binding; receptor activity; transforming growth factor beta binding;
  • Synonyms
  • ITGAV; integrin, alpha V; antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR; integrin alpha-V; CD51; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); MSK8; VNRA; VTNR; DKFZp686A08142;

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